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Although it is unclear if this risk extends to humans, patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are advised against using these medications
In preclinical models it has been associated with cytoprotection , modulation of nitric-oxide pathways and angiogenesis , with reported activity across gastrointestinal, musculoskeletal and other tissues [1] [2]
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eLife 2 , e01202 (2013)
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